Therefore, we further discussed whether lncRNA UCA1 could control EMT of NPC cells. UCA1 in stage + IV of NPC tissues and in patients with lymph node metastasis was significantly higher than that in patients at stage + and in patients without lymph node metastasis. Inhibition of UCA1 repressed proliferation, EMT, colony formation, invasion and migration while stimulating apoptosis of NPC cells. Conclusion: Our study suggests that UCA1 expression was overexpressed in NPC. Additionally, UCA1 suppression could inhibit proliferation, EMT, invasion and migration, and promote apoptosis of NPC cells. PHT-427 the data; N =?68; **, BMP13 ?0.05; Table 2). Table 2. Relationship between expression of UCA1 and clinicopathological characteristics of nasopharyngeal carcinoma. >?0.05), but the PHT-427 proliferation rate of the UCA1 siRNA group was significantly slower than that of the NC group, and the proliferation rate was decreased significantly (?0.05), but the colony number of the UCA1 siRNA group was significantly lower than that of the NC group (?0.05). Compared with the blank group and the NC group, the cells in G0/G1 phase in.