C. , Ross , C. group died, using a mean success period of four weeks; 3 from the Pifithrin-u 8 mice that received 9.25 MBq survived up to 120 times without sign of liver metastasis). These data provide further proof that micrometastasis is an excellent focus on of radioimmunotherapy, and an utilized dose of significantly less than 20 Gy can successfully control little metastatic lesions. solid course=”kwd-title” Keywords: Radioimmunotherapy, Monoclonal antibody, Liver organ metastasis, Absorbed dosage estimation, Carcinoembryonic antigen Personal references 1) Press , O. W. , Eary , J. F. , Appelbaum , F. R. , Martin , P. J. , Nelp , W. B. , Glenn , S. , Fisher , D. R. , Porter , B. , Matthews , D. C. , Gooley , T. and Bernstein , I. D.Stage II trial of 131IB1 (anti\Compact disc20) antibody therapy with autologous stem cell transplantation for relapsed B cell lymphomas . Lancet , 346 , 336 C 340 ( 1995. ). [PubMed] [Google Scholar] 2) Kaminski , M. S. , Zasadny , K. R. , Francis , I. R. , Fenner , M. C. , Ross , C. W. , Milik , A. W. , Estes , J. , Tuck , M. , Regan , D. , Fisher , S. , Glenn , S. D. and Wahl , R. L.Iodine\131\anti\B1 radioimmunotherapy for B\cell lymphoma . J. Clin. Oncol. , 14 , 1974 C 1981 ( 1996. ). [PubMed] [Google Scholar] 3) Behr , T. M. , Sharkey , R. M. , Juweid , M. E. , Dunn , R. M. , Vagg , R. C. , Ying , Z. , Zhang , C.\H. , Swayne , L. C. , Vardi , Y. , Siegel , J. A. and Goldenberg , D. M.Stage I actually/II clinical radioimmunotherapy with an iodine\131\labeled anti\carcinoembryonic antigen murine monoclonal antibody IgG . J. Nucl. Med. , 38 , 858 C 870 ( 1997. ). [PubMed] [Google Scholar] 4) Sato , N. , Saga , T. , Sakahara , H. , Nakamoto , Y. , Zhao , S. , Iida , Y. , Kuroki , M. , Matsuoka , Y. and Konishi , J.Intratumoral distribution of radiolabeled radioimmunotherapy and antibody in experimental liver organ metastases style of nude mouse . J. Nucl. Med. , 40 ( 1999. ), in press . [PubMed] [Google Scholar] 5) Vogel , C. A. , Galmiche , M. C. and Buchegger , F.Radioimmunotherapy and fractionated radiotherapy of individual colon cancer liver organ metastases in nude mice . Cancers Res. , 57 , 447 C 453 ( 1997. ). [PubMed] [Google Scholar] 6) Juweid , M. E. , Sharkey , R. M. , Behr , T. , Swayne , L. C. , Dunn , R. , Siegel , J. and Goldenberg , D. M.Radioimmunotherapy of sufferers with little\quantity tumors using iodine\131 labeled anti\CEA monoclonal antibody NP\4 F(stomach)2 . J. Nucl. Med. , 37 , 1504 C 1510 ( 1996. ). [PubMed] [Google Scholar] 7) Warren , R. S. , Yuan , H. , Matli , M. R. , Gillett , N. A. and Ferrara , N.Legislation by vascular endothelial development factor of individual cancer of the colon tumorigenesis in Pifithrin-u mouse style of experimental liver organ metastasis . J. Clin. Invest. , 95 , 1789 Pifithrin-u C 1797 ( 1995. ). [PMC free of charge content] [PubMed] [Google Scholar] 8) Matsuoka , Y. , Kuroki , M. , Koga , Y. Mouse monoclonal to R-spondin1 , Kuriyama , H. , Mori , T. and Kosaki , G.Immunochemical differences among carcinoembryonic antigen in tumor tissues and related antigens in mature and meconium feces . Cancer tumor Res. , 42 , 2012 C 2018 ( 1982. ). [PubMed] [Google Scholar] 9).